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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T20513 | IDO1-IN-1 | IDO1 inhibitor 1,2 HzBTZ,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1 | IDO |
IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. | |||
T11901 | IDO1-IN-5 | IDO , Indoleamine 2,3-Dioxygenase (IDO) | |
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. | |||
T39839 | IDO1-IN-11 | IDO1-IN-11 | |
IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM. | |||
T39888 | IDO1-IN-7 | IDO1-IN-7 | |
IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstr... | |||
T39946 | IDO1-IN-12 | IDO1-IN-12 | |
IDO1-IN-12 is a potent and orally available IDO1 inhibitor. | |||
T11624 | IDO1-IN-2 | IDO | |
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. | |||
T12801 | (S)-IDO1-IN-5 | Others | |
(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 µΜ). | |||
T12668 | (Rac)-IDO1-IN-5 | Others | |
(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature he... | |||
T63222 | IDO1/2-IN-1 | ||
IDO1/2-IN-1 is the first potent, orally active dual IDO1/IDO2 inhibitor, exhibiting antitumor effects with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. | |||
T61385 | IDO1/TDO-IN-1 | ||
IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhi... | |||
T63651 | IDO1/2-IN-1 hydrochloride | ||
IDO1/2-IN-1 hydrochloride is the first potent dual inhibitor of IDO1 (IC50: 28 nM) and IDO2 (IC50: 144 nM) that is orally active.IDO1/2-IN-1 hydrochloride exhibits antitumor effects. | |||
T11616 | IDO-IN-13 | GS-4361 | IDO , Indoleamine 2,3-Dioxygenase (IDO) |
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM). | |||
T61140 | IDO1/TDO-IN-3 | ||
IDO1/TDO-IN-3 is a powerful inhibitor targeting IDO1 and TDO enzymes. It displays noteworthy effectiveness against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). Additionally, IDO1/TDO-IN-3 demonstrates considerable in ... | |||
T82082 | IDO1-IN-23 | Indoleamine 2,3-Dioxygenase (IDO) | |
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1]. | |||
T63780 | IDO1-IN-16 | ||
IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM). | |||
T61789 | IDO1-IN-14 | ||
IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeL... | |||
T60499 | IDO1/TDO-IN-2 | ||
IDO1/TDO-IN-2 (Compound 1) is a potent IDO1/TDO dual inhibitor with IC50s of 0.1 and 0.07 μM, respectively. IDO1/TDO-IN-2 has the potential for cancer research[1]. | |||
T78687 | IDO1-IN-21 | Indoleamine 2,3-Dioxygenase (IDO) | |
IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1]. | |||
T78795 | IDO1/TDO-IN-6 | Indoleamine 2,3-Dioxygenase (IDO) | |
IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO. The compound further demonstrates Ki values of 1.9 μM for IDO1 and 3.1 μM for TDO, m... | |||
T60318 | IDO1/TDO-IN-4 | ||
IDO1/TDO-IN-4 displays potent inhibition of both IDO1 (IC50 = 3.53 μM) and TDO (IC50 = 1.15 μM) and has an acceptable safety profile and pharmacokinetic properties. IDO1/TDO-IN-4 forms a hydrogen bond with IDO1, and π π ... |